Optical Photothermal Infrared Spectroscopy & Microscopy

Sub-micron IR with simultaneous Raman spectroscopy, co-located Fluorescence and high-speed label free IR imaging

Advancing the frontiers of IR spectroscopy

Photothermal Spectroscopy Corp. is advancing the frontiers of vibrational spectroscopy and imaging with its breakthrough Optical Photothermal Infrared (O-PTIR) technology. O-PTIR overcomes key limitations of traditional FTIR such as poor spatial chemical resolution, time-consuming sample preparation and spectral artifacts.

O-PTIR uniquely enables multimodal capabilities for spectroscopy, imaging, and microscopy, providing simultaneous sub-micron IR and Raman imaging, as well as co-located O-PTIR and Fluorescence microscopy.

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Advance capabilities with a broad application range

These advanced capabilities empower scientists to conduct high-impact research in areas such as life science, microplastics, materials science, and bio-pharma.

In industry, O-PTIR helps engineers and scientists solve critical problems and accelerate data acquisition in areas such as organic contamination, material composition, and failure analysis.

Need more information?

Discover how O-PTIR technology can elevate your research or help solve your toughest challenges. Our team are happy to assist and answer your questions.

Explore our products

Fluorescence guided sub-micron IR and simultaneous Raman spectroscopy: A world first and only

Widefield fluorescence-detected sub-500nm infrared multimodal microscopy

Simultaneous, submicron IR and Raman microscopy O-PTIR and Raman microscope combined.

Sub-micron IR sub-micron IR spectroscopy and imaging with FTIR quality data.

Applications

Multi-modal optical photothermal Infrared spectroscopy is being applied successfully to an increasingly broad range of applications in both academic and industrial labs. Learn more about how O-PTIR can help you advance your research or help solve your critical problems.

Life Science

Microplastics

Semiconductor

Material Science

Polymers

Biopharma

Resent webinars

Biopharma

Submicron IR+Raman analysis of biopharmaceuticals

This webinar will discuss the adverse impact of particulate matter and aggregates for immunogenicity and the need to improve the characterization of submicron aggregates/particles in biopharmaceuticals.

Biopharma

Simultaneously multi-modal (IR/Raman/FL) sub-micron IR (O-PTIR) spectroscopy for life science and biopharma applications

This webinar will discuss an overview of multimodal O-PTIR techniques and how it is uniquely addresses applications in Life science and Biopharma applications overcoming limitations of FTIR and Raman techniques.

Products & Techniques

Sub-500nm, widefield IR (O-PTIR) chemical and simultaneous fluorescence imaging

Please join Dr Mustafa Kansiz, Director of Product Management and Marketing at Photothermal Spectroscopy Corp (PSC) for this exciting two-part event introducing the new mIRage-LS, multimodal microscope.

Semiconductor

Identifying organic contaminants with Sub-micron IR and simultaneous Raman with fluorescence imaging

Learn how submicron IR (O-PTIR) spectroscopy, simultaneous Raman and co-located widefield fluorescence imaging is being applied for failure analysis and organic contamination identification of small, sub-surface and complex layers and particles in microelectronics and semiconductor components.

Life Science

Label free chemical imaging of fresh, hydrated living tissues and embryos with submicron IR (O-PTIR)

Please join Prof Oxana Klementieva, Lund University, in this webinar based on her publication to learn how typical IR spectra and chemical IR images, at submicron resolution were acquired without water interferences in the protein bands, on freshly prepared and hydrated biopsies, tissue slices, and living organisms without compromising sample viability and function.

"I am very excited about new possibilities that can now be achieved with fluorescence guided OPTIR on the mIRage-LS for biomedical research. The new instrument offers a dream setup for microspectroscopic experiments."

Oxana Klementieva, Ph.DAssociate Professor, Lund University, Sweden

“The capability of the mIRage system to provide submicron simultaneous IR+Raman is truly unique and offers significant advantages compared to other technologies. Moreover, Photothermal team have been amazing to work with!”

Tanya Hutter Ph.DAssistant Professor The University of Texas at Austin

“Our first user experiment in the field of Alzheimer’s went so well that the researchers are submitting a manuscript to a high impact journal. The OPTIR is a disruptive technology.”

Ferenc Borondics, Ph.DPrincipal Beamline Scientist SOLEIL synchrotron France

“mIRage is truly extraordinary. Within weeks of installation we finished measurements for our first paper. It should be called the ‘mIRacle‘! “

Agnieszka Banas, Ph.DSenior Research Fellow Singapore Synchrotron Light Source (SSLS)

Upcoming event

The European symposium on optical photothermal infrared spectroscopy

June 3-4, 2025

Jagiellonian University, Krakow, Poland

The EurO-PTIR symposium brings together researchers from the field of vibrational spectroscopy to learn about the research and applications of multimodal O-PTIR, including simultaneous Raman and co-located Fluorescence microscopy across a broad range of research areas including life sciences, environmental sciences, (bio)pharmaceuticals, polymers, material sciences and beyond

Events

Workshop

Temple University

Founded as a night school by Russell Conwell in 1884, Temple University has evolved into an international powerhouse in higher education and a top research institution with over 30,000 undergraduate, graduate and professional students.

News

November 18, 2024

New Tutorial Highlights O-PTIR Microscopy’s Breakthroughs in Chemical Imaging

November 18, 2024

Congressman Carbajal Announces $283,000 CHIPS Act Grant for Santa Barbara Business

September 25, 2024

CHIPS ACT, SBIR innovation Award for Photothermal Spectroscopy Corp.

August 14, 2024

Curt Marcott wins 2023 NY/NJ Society of Applied Spectroscopy Gold Medal Award

Publications

Many of our customer publications highlight breakthroughs in science detailed in high impact publications. These breakthroughs cover a wide range of scientific research from the frontiers of bioimaging, to sub-micron IR measurement of microplastics, and achieving single molecule imaging resolution with combined SERS/SIERA measurement.

Need more information?

Discover how O-PTIR technology can elevate your research or help solve your toughest challenges. Our team are happy to assist and answer your questions.